Willem M. de Vos received a PhD degree with highest honors at State University of Groningen, the Netherlands, on work in the area of Molecular Genetics, which was partly done at the Max Planck Institute in Berlin, Germany. He received a post-doctoral fellowship of the EU Biomolecular Engineering Programme to stay in the United Kingdom and then became research manager at NIZO, the research institute of the Netherlands dairy industry.

There he established a research group on lactic acid bacteria and became first Professor of Bacterial Genetics and later the Chair of Microbiology at Wageningen University, the Netherlands, where he initiated research groups on the biotechnology of extremophiles and archaea, as well as on the microbial ecology of the intestinal tract. In this function, he first served as Director of the Department of Biomolecular Sciences and in 2000 became a Programme Director on Microbial Functionality and Safety at the Wageningen Centre for Food Sciences (WCFS), a public-private centre of excellence in the Netherlands. He has received several international awards, including the Rhone Poulenc Dairy Science Award.

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